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Fig. 1 | Cell & Bioscience

Fig. 1

From: GPR116 receptor regulates the antitumor function of NK cells via Gαq/HIF1α/NF-κB signaling pathway as a potential immune checkpoint

Fig. 1

Knockout of GPR116 inhibits pancreatic cancer growth in mice by affecting the infiltration and function of NK cells. A The photo of PAAD tumor sizes (n = 5). B The PAAD tumor growth curves and the end-point tumor sizes were represented (n = 5). C The weight of PAAD tumor (n = 5). D The infiltration of CD3+ T cells in PAAD tumor. E The proportion of CD4+ and CD8+ T cells in PAAD tumor. F The infiltration of CD3 NK1.1+ cells in PAAD tumor. G The expression of GzmB in tumor-infiltrating CD3+ T cells. H The expression of GzmB in tumor-infiltrating CD3 NK1.1+ cells. I The expression of IFNγ in tumor-infiltrating CD3 NK1.1+ cells. All data are from at least three independent experiments. Data are represented as the mean ± standard error of the mean (SEM). ns no significance, *P < 0.05, **P < 0.01, ***P < 0.001 by an unpaired Student’s t-test

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