Fig. 6From: A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat dietOptical microscope images of the hippocampus a–c and representative magnification images of dendritic spines of each experimental group d–e. g–j. Quantification of dendritic spines of each 30 µm of dendrite in different areas of the hippocampus (n = 5). Groups were compared against each other using one-way ANOVA and Tukey post-test, * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001 k. Representative images of synaptic proteins levels were determined, where two representative samples out of four or five per group are shown (n = 4–5). Graphs barts represent mean ± SD. Data were analyzed by one-way ANOVA and Tukey’s post-test, * p < 0.05, ** p < 0.01 and *** p < 0.001. l. Quantification of BDNF protein levels in the cortex (n = 7). Data were analyzed by one-way ANOVA and Tukey’s post-test, ** p < 0.01Back to article page