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Fig. 4 | Cell & Bioscience

Fig. 4

From: A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet

Fig. 4

ac. Illustrative images of Aβ plaques in the hippocampus and cortex. Scale bar: 200 µm. Graphic representation of Aβ plaques quantification in d. hippocampus and e. cortex (n = 5 independent samples per group, with at least 5 slices analyzed per sample). In hippocampus analysis, Mann–Whitney test was performed, * p < 0.05. In cortex analysis, t-test was performed, where * p < 0.05. f. Measurement of the levels of Aβ42 peptide in the cortex (n = 7). Statistical analysis was performed by T-test, where * p < 0.05. g. Determination of β-secretase activity in the hippocampus (n = 7). Data were analyzed by one-way ANOVA and Tukey’s post-test, where * p < 0.05 and ** p < 0.01 h. APP processing related protein levels. Two representative samples out of four or five per group are shown (n = 4–5). All results were represented as mean ± SD. Groups were compared against each other using one-way ANOVA and Tukey post-test, * p < 0.05, ** p < 0.01 and **** p < 0.0001

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