Fig. 2

a. Analysis and representation of changes in body weight (n = 13 animals per group). b. GTT and d. ITT experiment profiles (n = 13 animals per group). Area under curve (AUC) data were calculated from the time point 0 until the end of the experiment for both c. GTT and e. ITT. f. Semi-quantification of IRS2 levels in the liver where two representative samples out of four or five per group are shown (n = 4–5). All results were represented as mean ± SD. Statistical analysis was conducted through one-way ANOVA and Tukey post-test, except in the case of the analysis of weights, where the Kruskal–Wallis test was performed. In all cases, ** p < 0.01, *** p < 0.001 and **** p < 0.0001