Fig. 3
From: Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves
Aortic valve fibrosis in FSP1-cre+/SmoM2.+ mice. A shows pentachrome staining of fibrotic tissue (yellow suggestive of collagen diposition). Please note collagen deposition and size of the aortic valve hinge region and annulus. * shows the site with potential calcification. B shows the average of the aortic valve root thickness from 8 mice. # indicates significant difference (p < 0.05) between FSP1-cre + Smo- (or wild-type) mice and FSP1-cre + Smo + mice. C shows gene expression levels of hedgehog target genes Gli1, Hip1, and other genes (Pai1 and Spp1) known to be involved in fibrosis. # indicates significant changes in comparison with aortic valves from control mice (p < 0.05). The control value is set as 1