Fig. 5
From: Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity
Parkin deficiency is not involved in OVX-induced bone loss. A, B Femurs from WT (n = 5, each) and Parkin−/− (n = 5, each) female mice-subjected to sham or OVX were isolated, fixed in 4% paraformaldehyde, and then examined by micro-CT imaging. A Representative images of femoral bones of different groups. B The histograms represent three-dimensional structural parameters of the femurs: bone mineral density (BMD), bone volume per tissue volume (BV/TV), trabecular thickness (Tb. Th), trabecular number (Tb. N), trabecular separation (Tb. Sp), total porosity (%), or structure model index (SMI). Statistical analysis involved ANOVA, followed by the Kruskal–Wallis test using Prism version 3.0 software. *P < 0.05, **P < 0.005, or ***P < 0.001 compared with indicated group, n.s. indicates not significant