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Fig. 6 | Cell & Bioscience

Fig. 6

From: AMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation

Fig. 6

GDC-0449 and TPCA-1 synergistically suppresses DAOY growth and progression. A Dose–effect curve demonstrates the relationship between Fa and Dose. B The Combination index (CI) of GDC-0449 and TPCA-1. C Sensitization of TPCA-1. D Proliferation of PRKAA1−/− DAOYs treated with GDC-0449 or TPCA-1 subjected to CCK-8 assay. Migration E and invasion G abilities of PRKAA1−/− DAOYs treated with GDC-0449 or TPCA-1 evaluated by transwell assays with and without matrigel. (F) and (H) are quantification data of three independent experiments as in (E) and (G). RT-PCR detection of mRNAs of NF-κB downstream target genes CCL3 (I), CCL5 (J), CXCL10 (K), and VCAM1 (L) in PRKAA1−/− DAOYs treated with drugs. Data in bar graphs are performed as mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001, ns not significant

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