Fig. 1

Schematic of the brain nuclear receptors regulate cardiovascular function. ER in the RVLM and the PVH decreases SAP and protects against aldosterone-induced hypertension; THR in the AH increases heart rate and blood pressure; MR in the NTS and the Amy increases salt appetite and signals salt satiation. MR-NTS neurons project to the PBN, PVH, and BNST, modulating sensory coding of salt taste and signaling salt satiation. ER estrogen receptor, RVLM rostral ventrolateral medulla, PVH paraventricular nucleus of the hypothalamus, SAP systolic arterial pressure, THR thyroid hormone receptor, AH anterior hypothalamus, MR mineralocorticoid receptor, NTS nucleus tractus solitarius, Amy amygdala, PBN parabrachial nucleus, BNST bed nucleus of the stria terminalis