Fig. 4
From: Loss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes
TET2 regulates STAT3 target genes in ECs. A Schematic illustration of samples preparation for RNA sequencing. B Principal component analysis for HUVECs transfected with Ctrl siRNA or TET2 siRNA. C Volcano plots to determine differentially expressed genes for HUVECs transfected with Ctrl siRNA or TET2 siRNA. GO enrichment analysis of the upregulated genes D and downregulated genes E in different biologic response of AdTET2 compared with AdCtrl. F GSVA of the expression of several genes were performed with role in different signaling pathways from RNA-sequencing. G GSEA of the genes in the IL-6_JAK_STAT3 pathway generated from RNA sequencing