Table 2 The dynamic changes of chromatin remodeling modification/factors in neurodegenerative diseases
From: Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
Neurodegenerative diseases | Chromatin remodeling modification/factors | Changes in Diseases | References |
|---|---|---|---|
Alzheimer’s disease (AD) | H4 acetylation | Decreased | |
H3K27ac | Global increased | [169] | |
H3K9me2 | Increased | [177] | |
DNA methylation | Not certain | ||
HDAC1 | Decreased | [174] | |
HDAC2 | Increased | [230] | |
HDAC3 | Increased | ||
HDAC6 | Increased | [171] | |
EHMT1 | Increased | [177] | |
Parkinson’s disease (PD) | H3K14ac | Increased | [182] |
H3K18ac | Increased | [182] | |
HDAC2 | Increased | [231] | |
Huntington’s disease (HD) | H3K9me3 | Increased | [188] |
H3K4me3 | Decreased | [189] | |
HDAC1 | Increased | [193] | |
HDAC2 | Increased | [232] | |
HDAC3 | Increased | ||
HDAC4 | Increased | [194] | |
H2AFY | Increased | [195] | |
Amyotrophic lateral sclerosis (ALS) | H3K14ac | Decreased | [196] |
H3K56ac | Decreased | [196] | |
H4K12ac | Increased | [196] | |
H4K16ac | Increased | [196] | |
HDAC11 | Decreased | [197] | |
HDAC2 | Increased | [197] | |
H2B Thr129 and Ser10 phosphorylation | Decreased | [196] | |
H3 Thr129 and Ser10 phosphorylation | Decreased | ||
Amyotrophic lateral sclerosis (ALS) | H3K9me3 | Increased | [201] |
H3K27me3 | Increased | [201] | |
H4K20me3 | Increased | [201] | |
H2A K119 ubiquitination | Decreased | [202] | |
DNMT1 | Increased | [214] | |
DNMT3a | Increased | [214] | |
Mitochondrial DNA methylation | Increased | [216] | |
CHD1 | Decreased | [221] | |
CHD2 | Decreased | [221] | |
nBAF | Decreased | [224] |