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Fig. 5 | Cell & Bioscience

Fig. 5

From: Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification

Fig. 5

Piezo1 agonist Yoda1 reduced the methylation of intestinal mucosa in WAS model mice. A Immunofluorescence for co-localization of AGR2 and H3K9me3 in intestinal mucosa of control, WAS and WAS + Yoda1 mice; bar length: 20 μm. B Immunofluorescence for co-localization of AGR2 and Piezo1 in intestinal mucosa of control, WAS and WAS + Yoda1 mice; bar length: 20 μm. C Western blot of Piezo1, Suv39h1, Hdac3, GAPDH, H3K9me3 and T-H3 in the control and WAS mice (n ≥ 6). D Statistical analysis of protein in panel C. E RT-PCR of Piezo1, EDEM1, GRP78, ATF4 mRNA in the mucosa of control, WAS and WAS + Yoda1 mice (n ≥ 6). F Schematic showed that Yoda1 reduced the H3K9me3 modification on the mucin2 promoter by reducing Hdac3 and SUV39h1

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Cell & Bioscience

ISSN: 2045-3701

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