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Fig. 10 | Cell & Bioscience

Fig. 10

From: Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification

Fig. 10

The schematic diagram of the mechanism by which the intestinal motility of WAS mice changes the colonic mucus barrier by acting on Piezo1 to regulate downstream methylation. Left side: Piezo1 on goblet cells of WAS mice decreased, and the decline of intestinal motility in WAS mice led to the downregulated signal of Piezo1 reception, which together led to the weakening of the inhibitory effect of piezo1 on downstream SUV39h1. Enhancement of SUV39h1 promoted H3K9me3 modification on the mucin2 promoter of goblet cells, resulting in the decrease of mucin2, mucus thickness and the increase in bacterial permeability. Right side: Addition of Yoda1 activates Piezo1 protein on intestinal goblet cells, inhibits downstream SUV39h1 and Hdac3, and reduces the binding of H3K9me3 to mucin2 promoter. After H3K9me3 isolation from mucin2 promoter, mucin2 gene was activated. Intestinal goblet cells synthesize and secrete more mucin2. The mucus thickness of WAS mice increased and the mucus barrier permeability improved

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Cell & Bioscience

ISSN: 2045-3701

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