Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3

Hong, Namgue; Kim, Hee Jung; Kang, Keunsoo; Park, Ji On; Mun, Seyoung; Kim, Hyung-Gun; Kang, Bong Hui; Chung, Phil-Sang; Lee, Min Young; Ahn, Jin-Chul

doi:10.1186/s13578-022-00949-6

Table 3 Statistical analysis of entire figures

From: Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3

Figure no.	Condition	Gaussian distribution	Column analyses	ANOVA value	ANOVA P value	P value
Figure 2B		SW	ANOVA	F = 11.21	P < 0.0001	**p = 0.0052
Figure 2B		SW	ANOVA	F = 11.21	P < 0.0001	***p = 0.0001
Figure 2C		AP	ANOVA	F = 22.92	P < 0.0001	****p < 0.0001
Figure 2C		AP	ANOVA	F = 22.92	P < 0.0001	***p = 0.0001
Figure 2D			KW	KW = 53.74	P < 0.0001	****p < 0.0001
Figure 2D			KW	KW = 53.74	P < 0.0001	***p = 0.0009
Figure 2E			KW	KW = 45.29	P < 0.0001	****p < 0.0001
Figure 2F			KW	KW = 28.1	P < 0.0001	***p = 0.0004
Figure 2F			KW	KW = 28.1	P < 0.0001	*p = 0.0129
Figure 2G			KW	KW = 72.75	P < 0.0001	****p < 0.0001
Figure 2H			KW	KW = 46.67	P < 0.0001	***p = 0.0005
Figure 2H			KW	KW = 46.67	P < 0.0001	****p < 0.0001
Figure 2I		SW	ANOVA	F = 29.84	P < 0.0001	**p = 0.0095
						*p = 0.0186
						****p < 0.0001
Figure 3B			2way ANOVA	Row F = 32.41 Column F = 7.594	P < 0.0001 P = 0.0218	*p = 0.0261
Figure 4B			KW	KW = 29.81	P < 0.0001	****p < 0.0001
Figure 4C		SW	ANOVA	F = 22.54	P < 0.0001	****p < 0.0001
Figure 4D		AP	ANOVA	F = 31.49	P < 0.0001	****p < 0.0001
Figure 4D		AP	ANOVA	F = 31.49	P < 0.0001	***p = 0.0009
Figure 5B	D + 3	AP	Unpaired t-test			***p = 0.0001
Figure 5B	D + 7	AP	Unpaired t-test			****p < 0.0001
Figure 5C	D + 3	KS	Unpaired t-test			****p < 0.0001
Figure 5C	D + 7	AP	Unpaired t-test			****p < 0.0001
Figure 5D	D + 3		MW	MWU = 1		****p < 0.0001
Figure 5D	D + 7		MW	MWU = 60		****p < 0.0001
Figure 6B	CA1	SW	ANOVA	F = 27.19	P < 0.0001	***p = 0.0004
	CA1			F = 27.19	P < 0.0001	^####p < 0.0001
	CA3			F = 23.19	P < 0.0001	***p = 0.0008
	CA3			F = 23.19	P < 0.0001	^###p = 0.0001
	Hilus			F = 22.79	P < 0.0001	***p = 0.0004
	Hilus			F = 22.79	P < 0.0001	###p = 0.0003
Figure 6C	CA1	SW	ANOVA	F = 4.547	P = 0.0339	#p = 0.0467
	CA3			F = 9.805	P = 0.003	*p = 0.025
	CA3			F = 9.805	P = 0.003	^##p = 0.0042
	Hilus			F = 34.49	P < 0.0001	***p = 0.0002
	Hilus			F = 34.49	P < 0.0001	^####p < 0.0001
Figure 6D	GFAP		MW	MWU = 0		***p = 0.0006
Figure 6D	Iba1	SW	Unpaired t-test			****p < 0.0001
Figure 6E		AP	Unpaired t-test			****p < 0.0001
Figure 6F		AP	Unpaired t-test			**p = 0.0014
Figure 7C		SW	ANOVA	F = 114.6	P < 0.0001	****p < 0.0001
Figure 7C		SW	ANOVA	F = 114.6	P < 0.0001	***p = 0.0004
Figure 7E		AP	ANOVA	F = 6.893	P = 0.0008	**p = 0.0012
Figure 7E		AP	ANOVA	F = 6.893	P = 0.0008	*p = 0.0288
Figure 7G		AP	ANOVA	F = 14.42	P < 0.0001	*p = 0.0195
Figure 7G		AP	ANOVA	F = 14.42	P < 0.0001	****p < 0.0001
Figure 7H		AP	ANOVA	F = 10.44	P < 0.0001	**p = 0.0039
Figure 7H		AP	ANOVA	F = 10.44	P < 0.0001	****p < 0.0001
Figure 7J		SW	ANOVA	F = 8.665	P = 0.0012	**p = 0.0015
Figure 7J		SW	ANOVA	F = 8.665	P = 0.0012	*p = 0.0235
Figure 8B		AP	ANOVA	F = 11.9	P < 0.0001	*p = 0.0398
						**p = 0.0054
						^##p = 0.0018
						***p = 0.0001
Figure 8C		SW	ANOVA	F = 7.006	P < 0.0001	*p = 0.0111
						*p = 0.0401
						**p = 0.0094
Figure 8D		SW	ANOVA	F = 8.197	P < 0.0001	**p = 0.0015
						*p = 0.013
						^##p = 0.0093
Figure 8F		SW	ANOVA	F = 14.2	P < 0.0001	**p = 0.002
Figure 8F		SW	ANOVA	F = 14.2	P < 0.0001	****p < 0.0001
Figure 9B	PI		KW		P < 0.0001	**p = 0.0064
						***p = 0.0001
						****p < 0.0001
	PI + tPBM					^#p = 0.0287
						^##p = 0.0047
						^###p = 0.0002
						^####p < 0.0001
Figure 9C			MW	U = 137		**p = 0.0015
Figure 9D			Chi-Square	X² = 3.0647		*p = 0.08
Figure 9F		AP	ANOVA	F = 24.04	P < 0.0001	****p < 0.0001
Figure 9F		AP	ANOVA	F = 24.04	P < 0.0001	**p = 0.0053
Figure 9G		AP	ANOVA	F = 21.84	P < 0.0001	****p < 0.0001
Figure 9G		AP	ANOVA	F = 21.84	P < 0.0001	*p = 0.035
Figure 9H			KW		P = 0.0003	***p = 0.0005
Figure 9H			KW		P = 0.0003	*p = 0.014
Figure 9J		KS	ANOVA	F = 7.975	P = 0.004	**p = 0.0032
Figure 9L		AP	ANOVA	F = 13.43	P = 0.0004	***p = 0.0004
Figure 9L		AP	ANOVA	F = 13.43	P = 0.0004	*p = 0.012

AP D'Agostino & Pearson, SW Shapiro–Wilk, KS Kolmogorov–Smirnov, ANOVA one-way analysis of variance with Bonferroni post-hoc test, KW Kruskal–Wallis one-way analysis of variance with Dunn’s post-hoc test, MW two-tailed Mann–Whitney U test
*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, ^####p < 0.0001 relative to KA or PI

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ISSN: 2045-3701

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