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Fig. 4 | Cell & Bioscience

Fig. 4

From: Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3

Fig. 4

Neuroprotective effect of tPBM in the mouse hippocampus after PI-induced excitotoxicity as evaluated by CV staining. A Representative images of CV-stained brain coronal sections at 7 days after PI-induced SE. Treatment with 825 nm tPBM protected the CA1, CA3, and hilus cells of the hippocampus at 4 h after PI injection. Insets are zooms of the boxed areas showing CA1, CA3, and hilus hippocampal regions. Higher magnification views of each hippocampal region enclosed by black boxes. The scale bars indicate 500, 100, and 50 μm, respectively. B–D Quantitative analyses of the neuronal damage in hippocampal CA1, CA3, and hilus in the PI and PI + tPBM groups. CA1, cornu ammonis1; CA3, cornu ammonis 3. Data are expressed as the mean ± SEM; ***p < 0.001, ****p < 0.0001 relative to PI (ANOVA with the Bonferroni test)

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