Fig. 4

Inhibition of p110α suppresses the downstream effectors of the PI3K signaling pathway in neuroblastoma cells. a–e western blot showing inhibition of PI3K signaling in NBL-S cells or SH-SY5Y cells after PI3K inhibitors treatment (2 h). f PI3K signaling suppression revealed by western blot in KELLY cells, transfected with siPIK3CA (50 nM) or siControl (50 nM) for 48 h. β-Tubulin was blotted as the loading control