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Fig. 1 | Cell & Bioscience

Fig. 1

From: Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase

Fig. 1

The expression of p110α is correlated with neuroblastoma prognosis. a–c Kaplan–Meier analysis of overall survival probability in neuroblastoma patients, separated by PIK3CA (a), PIK3CB (b), PIK3CD (c) expression. Cut-off values were selected by Kaplan Scan (“Materials and methods” section). SEQC (seqcnb1) dataset was analyzed. d Expression of PIK3CA in 3 normal tissue datasets and 4 neuroblastoma datasets. The bar chart is presented by mean ± SD. eExpression of PIK3CA in neuroblastoma samples. Patient samples were categorized by risk stratification (e) or neuroblastoma stages (f). The bar charts were presented as mean ± SEM. SEQC (seqcnb1) dataset was used for the analysis. All the datasets were obtained from the R2: Genomics Analysis and Visualization Platform (https://r2.amc.nl). The Student’s t-test was used for statistical analysis. ***p < 0.001

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