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Fig. 7 | Cell & Bioscience

Fig. 7

From: Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity

Fig. 7

A Immunohistochemistry for the macrophage-specific markers, F4/80 and B CD68, in liver sections from the selected mouse groups (n ≥ 3/group) as well as healthy controls (n = 8), and patients with alcoholic cirrhosis (n = 8). Orig., magn. 10X; scale bar: 100 μm. For bar graphs, data are of 5 random fields mean ± SEM, *p < 0.05 vs. the respective control groups; #p < 0.05 vs. EtOH-fed WT mice. C qPCR for CXCL1 in total liver samples from healthy controls (n = 6) and patients with alcoholic cirrhosis (n = 16). Data are mean ± SEM. *p < 0.05 vs. heathy control samples. D Immunohistochemistry for MPO in liver sections from the selected groups of mice (n ≥ 3/group), healthy controls (n = 8), and patients with alcoholic cirrhosis (n = 8). Orig. magn. 20X for mouse and 10X for human, scale bar: 100 μm. E Immunohistochemical quantification of MPO in human liver sections. Data are mean ± SEM of 5 random fields. *p < 0.05 vs. healthy controls. F qPCR for the neutrophil marker, Ly6G, in healthy controls (n = 6) patients with alcoholic cirrhosis (n = 16). Data are mean ± SEM of two experiments for each sample. *p < 0.05 vs healthy control samples. Black arrows indicate MPO+ positive cells

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