Fig. 1
From: Targeting G-quadruplex for rescuing impaired chondrogenesis in WRN-deficient stem cells
WRN helicase resolves global G4 quadruplexes in multiple cell lines. Representative BG4 staining and quantitative analysis of G4 foci per nucleus in MSC, 293T and H1 cells. N > 47 for each cell type. Scale bar: 10 µm. t-test (2-tailed, unequal variance) compared to WRN−/−: *p < 0.05, ****p < 0.00005. a BG4 staining of WRN+/+ and WRN−/− with OE-WRN in MSC. b BG4 staining of WRN+/+ and WRN−/− 293T and H1 cells