Fig. 3

NR4A1 suppresses CC cells progression. A The mRNA expression of NR4A1 in CC were analyzed by GENT2 and GSE39001 datasets. For violin polts, midlines indicate the median, upper and lower lines indicate the first and third quartiles. B Representative images of IHC staining showed the protein levels of NR4A1 in CC tissues and paired adjacent nontumor tissues (n = 8, left) and quantitatively analyzed (right). C MTT assay showed the proliferative ability of CC cells. D The effect of NR4A1 on cell migration and invasion in CC cells. E The proliferative ability was investigated by colony formation. F Western blot assay of N-cadherin, Vimentin and E-cadherin protein levels in overexpression and knockdown of NR4A1 CC cells. All experiments were performed at least 3 independent times, and data are presented as means ± SD expect where otherwise specified. *P < 0.05, **P < 0.01, ***P < 0.001