Fig. 6
From: In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer
ZNF24-NF-κB signaling axis is clinically relevant. A Schematic model of ZNF24-P65-NF-κB signaling axis in lung cancer. B Expression of ZNF24 mRNA in lung cancer tissue and para-tumoral tissues of patients with TCGA (http://xena.ucsc.edu/). C K–M survival of lung cancer patient (all stage, n = 1927) (http://kmplot.com). D K–M survival of lung cancer patient (Stage I, n = 449) (http://kmplot.com). E–F Correlation between expression of ZNF24 and that of RelA or RelB. Expression data of lung adenocarcinoma cancer patients from TCGA database (analyzed through UCSC Xena). G, H and I Correlation between expression of ZNF24 and that of CCNE1, CDKN1A or CDKN1B. Expression data of lung adenocarcinoma cancer patients from TCGA database (analyzed through UCSC Xena). J, K Correlation between expression of ZNF24 and that of RelA or CDKN1B. Expression data of lung adenocarcinoma cancer patients positive for KRAS mutation from TCGA database (analyzed through UCSC Xena). L Correlation analysis of expression between ZNF24 and CDKN1B. Expression data of lung adenocarcinoma cancer patients positive for EGFR mutation from TCGA database (analyzed through UCSC Xena)