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Fig. 7 | Cell & Bioscience

Fig. 7

From: Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis

Fig. 7

Summary of the mechanism of this study. The increased MS, such as blood pressure, activates the Piezo1 channels and increases the intracellular Ca2+ level in JG cells. The increased [Ca2+]i induces the Ptgs2 (COX-2) expression via a calcineurin/NFAT pathway and subsequently an increased level of PGE2 secretion, which inhibits cAMP production through EP3 and downregulates renin expression

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Cell & Bioscience

ISSN: 2045-3701

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