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Fig. 3 | Cell & Bioscience

Fig. 3

From: Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains

Fig. 3

Differential regulation of proteins in schizophrenia patients versus control cells from human PSC-derived organoids, neurons, and NPCs. A Chord diagram overviewing individual proteins (purple lines) and pathways (blue lines) shared among comparisons. The numbers of proteins (total and overlapped) are detailed. B Functional network tree representation of enriched pathways, processes, and GO terms. Terms were grouped by similarity metric (kappa scores) and the most statistically significant term within a cluster was set to represent the cluster, according to Metascape analyses. C Canonical pathway analyses were performed using the Ingenuity pathway analyses dataset. The blue plot represents pathway enrichment (Log2 adjusted p-value), and the purple/green plot represents z-scores prediction of activation/inhibition of those pathways. Purple represents activated scores, and green represent inhibited scores

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