From: DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets
Pathogenesis | Key genes | DNA methylation status | References |
---|---|---|---|
Oxidative stress | PLOG1 | Hypermethylation | Mishra et al. [45] |
D-loop | Hypermethylation | Mishra et al. [45] | |
MLH1 | Hypermethylation | Mohammad et al. [52] | |
MMP-9 | Hypomethylation | Zhou et al. [54] | |
RAC1 | Hypomethylation | Duraisamy et al. [18] | |
PPARα | Hypermethylation | Zhu et al. [17] | |
MnSOD/SOD2 | Hypermethylation | Duraisamy et al. [49] | |
Inflammation | NLRP3, TGFβ1, MCP-1, TNFSF2 | Hypomethylation | Chen et al. [62] |
MALAT1 | Hypomethylation | Zhu et al. [17] | |
Neovascularization | MEG3 | Hypermethylation | He et al. [80] |
ETS1, HES5, PRDM16 | Unknown | Berdasco et al. [20] | |
Others | MTHFR | Hypermethylation | Dos Santos Nunes et al. [96] |
Santana Bezerra et al. [98] | |||
SIRT1 | Hypermethylation | Mishra et al. [101] | |
Chen et al. [102] |