Fig. 4
From: DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets
Process for aberrant DNA methylation of key genes inducing an inflammatory response in the retina. Diabetes contributes to hypomethylation of the promoter in inflammation-related genes. Finally, increased transcription and translation of inflammatory cytokines result in angiogenesis and neurodegeneration in retinopathy. Dnmts, DNA methyltransferases; Tets, ten-eleven translocation dioxygenases; 5hmC, 5-hydroxymethylcytosine