Fig. 4
From: PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders
Pathways of ROS and apoptosis for neuronal dysfunctions. a Molecular pathways regulating oxidative damage, mitochondrial dysfunction, and apoptosis associated with neuronal dysfunction and death, neurofibrillary tangles, motor disturbance and non-motor symptoms. DEGs in red squares were up-regulated in 45,XO-hPGCLCs during specification from 45,XO-hiPSCs in comparison with those of both 46,XX, and 46,XY. Red arrows indicated up-regulation. ROS, reactive oxygen species. b Heat map of up-regulated DEGs from (a) in 45,XO-hiPSCs (n = 3) and 45,XO-hPGCLCs (n = 2). c Spot plots showing expression of representative DEGs from (a) in 45,XO-hiPSCs (n = 3) and 45,XO-hPGCLCs (n = 2). Y-axis indicates expression levels (Log2 (FPKM + 1)). **P < 0.01