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Fig. 6 | Cell & Bioscience

Fig. 6

From: mTORC1-c-Myc pathway rewires methionine metabolism for HCC progression through suppressing SIRT4 mediated ADP ribosylation of MAT2A

Fig. 6

SIRT4 modulates gene expression by regulating methionine metabolism. A Western blot analysis of histone methylation level. Histone H3 was used as a loading control. B The mRNA levels of indicated genes were determined by quantitative real-time PCR (qRT-PCR) in the SNU449 cells. C The indicated proteins were assessed by western blot in the SNU449 or primary liver cells. Data are means ± SEM. Group differences were analyzed by two-way ANOVA followed by Tukey’s multiple comparison test (B, D) (**p < 0.01)

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Cell & Bioscience

ISSN: 2045-3701

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