Fig. 8
From: Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway
A graphic summary of the present study. A schematic drawing shows the working model of SAL-mediated neurite and mitochondrial protection in AD. Our findings suggest that SAL-mediated neurite and mitochondrial protection is dependent on SIRT3 expression. An elucidated mechanism of action is shown: SAL directly binds to transcription factor NRF2 and prevents its degradation by inhibiting the attachment of E3 ligase KEAP1, then promotes nuclear translocation of NRF2, and eventually favors SIRT3 transcription