Fig. 5
From: Salidroside reduces neuropathology in Alzheimer’s disease models by targeting NRF2/SIRT3 pathway
SAL-mediated cognitive protection is dependent on SIRT3. A A schematic overview shows the workflow of our animal study. B Quantitation shows the escape latency of mice from indicated groups from day 1 to day 5 during training. Significant differences are found in 5×FAD group compared to WT (**P < 0.01, ***P < 0.001) or 5×FAD+SAL group (##P < 0.01, ###P < 0.01). C Representative trajectories of mice from each group in MWM tests at day 6. Red square, starting point; blue square, ending point; platform (red circle) located in quadrant 2. Quantitation shows the traveled distance (D) and time spent (E) in the platform located quadrant. F Representative heatmap images show the visit frequency of mice in Y-maze. Arrow, the novel arm. Quantification shows the times of entry (G) and traveled distance (H) in the novel arm. All data are represented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, n.s., not significant; n ≥ 6; one-way ANOVA