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Fig. 5 | Cell & Bioscience

Fig. 5

From: An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

Fig. 5

Fyn-CDK5 pathway is activated in NP 60 min after exposure to media from microglia overexpressing Sema 3A. A Cartoon summarizing the proposed Sema 3A downstream pathway in NP exposed to Sema 3A media for 60 min. Representative WB analyses of Fyn pTyr420 and Fyn B, CDK5 pTyr15 C and CDK5/p35 D as well as of the correspondent β actin. OD analysis is reported on the right. Fyn, p35/CDK5 and CDK5 pTyr15 OD values were normalized to β actin and expressed as a percentage of Ctrl. Fyn pTyr420 levels were calculated as a ratio of Fyn pTyr420 relative to the corresponding Fyn OD values (Fyn pTyr420/Fyn). N = 3. One-way ANOVA followed by Tukey’s test for multiple comparisons. *P < 0.05; **P < 0.01

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