Fig. 4

A Sequence of images showing a THP-1 macrophage (green) contacting a wasteosome stained with PAS (red). Initially, a lamellipodium from a distant macrophage making contact with the wasteosome can be observed. Thereafter, the macrophage shrinks over the wasteosome and both structures displace together. However, unlike in the previous sets of experiments, the digestion of the PAS stained wasteosomes could not be observed in most of the experiments. B In only a few cases, as the one shown here, small amounts of fluorescence were observed to detach from the wasteosomes and spread inside the macrophages. See videos for details