Fig. 6
From: RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression
Hepatocyte-specific HuR deficiency enhances WDSW-induced dysregulation of bile acid homeostasis. a Relative mRNA levels of Cyp7a1, Cyp27a1, Shp, and Ntcp are shown and normalized with HPRT1 as an internal control in the liver of HuRhKO vs. Control mice fed with WDSW for 4 weeks. b BA composition profile in the liver is expressed by % of total BA. c TCA, the ratio of total primary conjugated BA to total primary unconjugated BA, the ratio of total conjugated BA to total unconjugated BA, and the ratio of total secondary conjugated BA to total secondary unconjugated BA in the liver. d Total BA, total unconjugated BA, total primary BA, and total secondary BA in the cecal contents. Data are expressed as the mean ± SEM. Statistical significance relative to control: * p < 0.05, ** p < 0.01, n = 8–12