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Fig. 3 | Cell & Bioscience

Fig. 3

From: RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression

Fig. 3

Hepatocyte-specific HuR deficiency enhances WDSW-induced inflammation and oxidative stress. a Representative images of immunohistochemistry (IHC) staining of F4/80 (scale bar, 100 μm for 10 × and 20 μm for 40 × magnification). Relative mRNA levels of genes involved in inflammation and oxidative stress were determined by real-time RT–PCR and normalized with HPRT1 as an internal control. b Macrophage markers: F4/80, Cd68, Cd63, and Cd11b; c Chemokines: Cxcl1, Cxcl10, Ccl2, and Ccr2; Inflammatory cytokines: IL1α, IL1β, Tnfα, and IL-6; d Neutrophil activation: Ncf4, Cybα, Cybβ, Ncf2, IL2rg, and Vcam1; Stress: Caspase 3 and Atf4. Data are expressed as the mean ± SEM. Statistical significance relative to control: * p < 0.05, ** p < 0.01, *** p < 0.001 (n = 12, male and female)

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