Fig. 1
From: RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression
Hepatocyte-specific HuR deficiency enhances WDSW-induced NAFLD. Age and gender-matched HuRhKO and control mice were fed ad libitum a high-fat diet with 42% kcal from fat and containing 0.1% cholesterol plus a high fructose-glucose solution (23.1 g/L d-fructose + 18.9 g/L d-glucose) (Western diet plus sugar water, WDSW) for 4 weeks. a Representative image of the liver and the liver sections stained with H&E and Oil red O staining (scale bar, 100 μm for 10 × magnification). b Serum liver enzyme levels (AST, ALT). c Hepatic triglyceride (TG) and total cholesterol (TC). d Bile acid composition profile in the serum is expressed by % of total bile acids. e Total bile acids (BA), total primary BA, TCA, and total conjugated BA in the serum. Data are expressed as mean ± SEM. Statistical significance: *p < 0.05 vs Control, n = 10–12 (both male and female)