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Fig. 7 | Cell & Bioscience

Fig. 7

From: CXCL12/CXCR7/β-arrestin1 biased signal promotes epithelial-to-mesenchymal transition of colorectal cancer by repressing miRNAs through YAP1 nuclear translocation

Fig. 7

YAP1 nuclear translocation is associated with EMT and metastasis in human CRC tissues. A Representative immunohistochemistry images of the expression of CXCR7, YAP1 and Vimentin in paired normal colonic tissues, CRC tissues and matched liver metastatic CRC tissues from CRC patients. Scale bar = 100, 50, 20 μm. B Western blot analysis of YAP1 and DCLK1 expression in 22 pairs of human CRC tissues and adjacent normal tissues. β-actin was used as an internal control. Statistical analysis was performed to compare the gene expression in colorectal cancer tissues (T) compared with adjacent normal colonic tissues (N). *P < 0.05. C The correlations of YAP1 with DCLK1 and Vimentin as well as association of CXCR7 with YAP1 were determined in CRC tissues by GEPIA. D RT-qPCR analysis of miR-124-3p levels in 22 pairs of human CRC tissues and adjacent normal tissues. E The correlation of miR-124-3p and Vimentin mRNA level was performed by Pearson correlation analysis (n = 40). *P < 0.05, **P < 0.01

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