Fig. 8
From: YAP1 protects against septic liver injury via ferroptosis resistance
The mechanism illustration on the involvement of YAP1 in ferritinophagy and ferroptosis in sepsis-induced liver injury. YAP1 inhibits ferritin degradation into autophagosomes via disrupting NCOA4–FTH1 interaction, preventing ferrous iron from being releasing into mitochondria, which subsequently restrains the accumulation of mitochondrial reactive oxygen species and lipid peroxidation, thus protects hepatocyte from ferroptosis. Therefore, YAP1 involves in sepsis-induced acute liver injury by regulating the process of ferritinophagy-mediated ferroptosis