Fig. 1
From: YAP1 protects against septic liver injury via ferroptosis resistance
YAP1 deficiency aggravated oxidative stress-mediated liver injury in CLP mice. 8–10-week-old control (YAP1flfl mice) and YAP1fl/fl Alb-Cre mice were randomly distributed into sham and CLP groups. A, B The certification of YAP1 conditional knockout in mice liver tissues, n = 3. C Histological images of liver samples exhibited by HE staining in YAP1fl/fl mice or YAP1fl/fl Alb-Cre mice with or without CLP treatment. D, E ALT and AST in liver tissue, n = 6. F, G Representative fluorescent images of ROS staining and the quantification of ROS fluorescence intensity in liver, n = 6. Liver content of GSH (H) and MDA (I) assessed by corresponding commercial kit, n = 6. J, L Representative images of the inflammatory cells infiltration as reflected by immunohistochemistry staining for CD68 and Ly6G in live and the quantification of fluorescence intensity, n = 6. M–O The levels of TNF-α, IL-1β and IL-6 in liver tissues of each group, n = 6. Data are expressed as mean ± SD of three replicates. *p < 0.05, **p < 0.01, ***p < 0.001