Table 1 Genes upregulated by hypoxia in LECs
From: The lymphatic vascular system: much more than just a sewer
Gene name | Function |
|---|---|
Long non-coding RNA H19 | Fibrosis |
Transforming growth factor-β 2, -3 | Fibrosis |
Prolyl 4-hydroxylase subunit alpha 1 | Proline-hydroxylation |
Procollagen-lysin 2-oxoglutarat 5-dioxygenase 2 | Lysine-hydroxylation |
Glucose transporter 3 (GLUT3/SLC2A3) | Vitamin C transport |
Tensin-1 | Myofibroblast differentiation |
Lysyl-oxidase | Cross-linking of collagen filaments; copper-dependent |
Ceruloplasmin | Copper transport |
Fibromodulin | Cohesion of collagen fiber bundles |
Tenascin-XB | Cohesion of collagen fiber bundles |
Inter-alpha-trypsin inhibitor heavy chain family member 5 | Inhibition of ECM degradation |