Fig. 1
From: Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer
The discovery pipeline and landscape of chimeric RNAs in prostate cancer. A The pipeline for discovering prostate cancer chimeric RNAs. The CCLE prostate related cell sequencing data were used for analysis. After filtering out of “M/M” fusions, GTEx fusions and PrEC LH fusions, 864 chimeric RNAs remain. 457 prostate cancer biased chimeric RNAs were identified after UCSC confirmation. B Circos plot depicting all identified chimeric RNAs in each prostate cell line. C Distributions of chimeric RNAs from HSPC, CRPC and NEPC. Chimeric RNAs were categorized based on their fusion type, junction position, and fusion protein coding potential. D Venn diagram shows the overlapping and specific chimeric RNAs among HSPC, CRPC, and NEPC. E–G Gene ontology analyses of parental genes involved in chimeric RNAs specific for HSPC, CRPC, and NEPC