Fig. 3
Transcriptomic analysis of the hippocampus in PND rat models. A, Volcano plot of differentially expressed genes (DEGs). HCN2, as a down-regulated DEG, was marked in the plot. B, the number of down-regulated and up-regulated DEGs. C, Up-regulated DEGs cluster heatmaps. D, Down-regulated DEGs cluster heatmaps. HCN2, as a down-regulated DEG, was marked in the plot. The horizontal axis is the z-score of the included sample, and the vertical axis is the gene’s name. The warmer the color block is, the higher the expression level is, and the colder the color block is, the lower the expression level is. PND group (n = 3) vs. control group (n = 3), |log2(fold change, FC)|> 1 and adjusted P < 0.05.