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Fig. 4 | Cell & Bioscience

Fig. 4

From: The regulatory role of AP-2β in monoaminergic neurotransmitter systems: insights on its signalling pathway, linked disorders and theragnostic potential

Fig. 4

The effect of AP-2β on serotonergic transmission in the brain. AP-2β enhances the 5-HT levels in the synaptic cleft by increasing the transcription Vmat [81] and repressing 5-HTT [19, 20, 101] and MAO-A [28, 91,92,93]. AP-2β has binding sites on TPH & AADC genes and 5-HT receptor [62, 102,103,104,105,106,107], but its effect on them is unknown. 5-HT: serotonin; Vmat: Drosophila vesicular monoamine transporter; 5-HTT: 5-HT transporters; MAO-A: monoamine oxidase-A; TPH: tryptophan hydroxylase; AADC: aromatic L‐Amino acid decarboxylase; 5-HT receptor: serotonin receptor

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