Fig. 1

The effects of NaIO₃ alone or in combination with melatonin on the proliferation of ARPE-19 cells. A ARPE-19 cells were treated with NaIO₃ (0, 2.5, 5, 10, 15, and 20 mM) for 24 h; cell viability was measured by MTT assay. B ARPE-19 cells were cotreated with NaIO₃ (15 mM) and melatonin at a series of concentrations (0, 0.5, 1, and 2 mM) for 24 h; cell viability was evaluated by MTT assay. C The morphology of ARPE-19 cells cotreated with NaIO₃ (15 mM) and melatonin at a series of concentrations (0, 1 and 2 mM) for 24 h. D The cell proliferation rate was determined from the results of a colony formation assay. All of the data are presented as the mean ± SEM of three independent experiments. **, P < 0.01 compared with the control; #, P < 0.05, ##, P < 0.01 compared with the NaIO₃ treatment group