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Fig. 5 | Cell & Bioscience

Fig. 5

From: TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation

Fig. 5

The SPRY domain and Ring domain of TRIM22 are required to interact and degrade with NS1 or NS3 protein, respectively. a Schematic diagram of the full length and four truncated forms of TRIM22. b Expression of the four TRIM22 truncations were determined by western blotting. c Whole-cell lysis of HEK293T cells co-transfected with pHis-NS1(upper) or NS3 (lower) and the indicated four truncated forms of TRIM22 were collected for IP with His tag antibody, followed by western blot analysis. d Western blot analysis of lysates from HEK293T cells co-transfected with pHis-NS1 (upper) or pHis-NS3 (lower) and pHA-TRIM22, pHA-TRIM22-Ring-deletion or vector control

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