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Fig. 2 | Cell & Bioscience

Fig. 2

From: Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits

Fig. 2

Cellular defense against oxidative stress during perinatal intermittent hypoxia in P12 mice. A Cell density (left) and average distance between cells (right) measured on DAPI-stained cerebellar slices of control (N) or hypoxic (IH) P12 mice. B Significant RT-qPCR results reflecting the regulation of the expression of genes involved in the antioxidant response to oxidative stress in the whole cerebellum of control (N) or hypoxic (IH) P12 mice. C Density of BrdU-immunoreactive cells in the EGL (left) and IGL (middle) and confocal images (right) illustrating the distribution of BrDU-positive cells in the cerebellar cortex in control (N) or hypoxic (IH) mice. For B, the number of animals was 15 for the N group and 10 for the IH group. For A and C, the total number of animals in each experimental group is indicated under the boxplots and represented by diamond shapes, while the transparent dots indicate individual data points. Exact p-values are indicated above the plot. BrdU: bromodeoxyuridine; EGL: external granular layer; IGL: internal granular layer; IH: intermittent hypoxia condition; N: normoxia condition; P12: postnatal day 12; ROS: reactive oxygen species

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