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Fig. 4 | Cell & Bioscience

Fig. 4

From: Plasma metabolomics provides new insights into the relationship between metabolites and outcomes and left ventricular remodeling of coronary artery disease

Fig. 4

Inference of potential causality and mediation effects between metabolites, LV remodeling, and outcomes. A Venn plot between metabolic signatures associated with LVEF, LVMI, and risks of death and MACE in the adjusted analysis. B Forest plot of metabolites associated with risks of death and MACE, LVEF, and LVMI identified by Mendelian randomisation analysis. HR of death and MACE were denoted using circle and square, estimates of LVEF and LVMI were denoted using triangle and diamond, respectively. C, D The percentage of association (mediation (%)) between metabolites and outcomes (death and MACE) by LVEF using mediation analyses

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