Table 1 Genomic features of the 13 SCLC cell lines used in this study and their sensitivity to GSK2126458 treatment
Cell Line | PIK3CA mutation/copy number | PTEN mutation | Relative level of p-AKT (T308)/(S473) | GSK2126458 IC50 ± SD (nM) |
|---|---|---|---|---|
NCI-H187 | WT/1.873 | WT | 0.348/0.753 | 21.2 ± 6.0 |
NCI-H446 | WT/NA | Exon 4, 46 bp deletion from codon 821 | 0.891/0.791 | 31.7 ± 13.8 |
NCI-H69 | G106-R108 del./3.693 | WT | 0.544/0.960 | 47.3 ± 19.2 |
NCI-H2081 | WT/NA | Missense Mutation, C124F2 | 0.240/0.782 | 158.4 ± 98.8 |
NCI-H1930 | WT/1.903 | WT | 0.064/0.231 | 285.3 ± 74.4 |
NCI-H841 | WT/copy number gain4 | WT | 0.434/0.295 | 329.6 ± 59.3 |
NCI-H2171 | WT/1.283 | WT | 0.043/0.051 | 358.8 ± 239.6 |
NCI-H82 | WT/1.693 | WT | ND/ND | 710.6 ± 204.4 |
NCI-H146 | WT/1.743 | WT | 0.033/0.021 | 1572.3 ± 388.4 |
NCI-H211 | WT/1.543 | WT | ND/ND | 2354.5 ± 973.3 |
NCI-H526 | WT/2.193 | WT | 0.019/ND | 2665.9 ± 1979.0 |
NCI-H524 | WT/1.663 | WT | 0.137/0.154 | 4035.2 ± 455.9 |
NCI-H345 | WT/3.453 | WT | 0.029/0.122 | 4622.3 ± 1183.9 |