Fig. 6
From: GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis
Mouse model of the early pathology of lung silicosis and expression of PPP2R3A in mouse lung tissue. A Sirius Red staining shows significantly greater collagen deposition in the lung tissue of the silica group than that of the saline group, which revealed that the model was successfully established. B Representative WB results showing higher PPP2R3A expression in the lung tissue of the silica group than that of the saline group. C *p < 0.05 indicates that the difference between the two groups is significant. D Immunohistochemical staining showing that PPP2R3A is expressed on fibroblasts. The expression level in the experimental group was higher than that in the control group. E The scRNA-Seq results show increased ppp2r3a expression in inflammatory-proliferative fibroblasts. F The scRNA-Seq results show that vimentin expression was increased in inflammatory-proliferative fibroblasts