Fig. 7From: Anti-tumor effects of dual PI3K-HDAC inhibitor CUDC-907 on activation of ROS-IRE1α-JNK-mediated cytotoxic autophagy in esophageal cancerWorking model for the mechanism of anti-tumor effect on CUDC-907. A working model showing how dual-inhibitor CUDC-907 activates cellular autophagy by inhibiting mTOR or downregulating LCN2 to accumulate ROS, thus, activating the IRE1α-JNK-CHOP cascadeBack to article page