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Fig. 6 | Cell & Bioscience

Fig. 6

From: SENP6 induces microglial polarization and neuroinflammation through de-SUMOylation of Annexin-A1 after cerebral ischaemia–reperfusion injury

Fig. 6

Knockdown of SENP6 in microglia/macrophages protects mice against focal ischaemic injury. A Schematic of adeno-associated virus vectors for SENP6 shRNA to downregulate SENP6 in microglia/macrophages. B Diagrammatic drawing of the whole experimental procedure. C Representative TTC staining indicating the ischaemia infarct volume. n = 8 mice in each group. D Quantification of infarct size in C. E Neurological deficit scores at different time points following MCAO surgery and reperfusion. Statistical differences in E were determined by RM ANOVA followed by Tukey’s post-hoc test. Data in D were assessed by one-way ANOVA followed by Dunnett’s post-hoc test. Data are presented as the mean ± S.E.M. n.s. for P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001

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