Fig. 1

CRLM1 is overexpressed in colorectal liver metastases and associated with poor survival. A Strategy of lncRNA CRLM1 identification by WGCNA and DEG analysis. B Module-trait association. Each row corresponds to a module and each column corresponds to a specific trait: normal related, primary tumor related, and metastasis tumor related. The color of the cell indicates the correlation coefficient between the module and trait, dark red color indicates high degree of positive correlation, and dark green indicates high degree of negative correlation between each module and trait. The numbers in the cell indicate the module-trait correlation value (top) and p value (below). C The unsupervised hierarchical clustering heatmap of 54 samples based on DElncRNAs between metastasis group and primary group. D Venn diagram of up-regulated lncRNAs in metastasis (vers. Primary) and the most metastasis-related module (MEgreen) detected by WGCNA. E Boxplot of expression level of CRLM1 in normal samples, primary and metastasis tumor samples. F Kaplan–Meier analysis for overall survival of patient with high or low CRLM1 in the colorectal cancer from TCGA dataset. G Expression of CRLM1 and the adjacent gene PPAP2B is positive correlated in metastasis. H Visualization of CRLM1 and the adjacent gene PPAP2B