Fig. 5

Results of gene regulatory network analysis. a The scatter plot shows the regulon-specific scores (RSSs) of all regulons and the threshold value of RSS with the red line. Only the regulons with RSSs > 0.6 were considered cell type-specific regulons (CTSRs). The IRF2 and IRF4 regulons are marked on the scatter plot. The TSNE plots show the distributions of MSC subsets and IRF2 and IRF4 regulon expression. b Circle plot showing the target genes of the IRF2 and IRF4 regulons. A higher number of target genes is indicated by a larger circle of the regulon. Each line represents a target gene, and the red line is CXCL12. c Heatmap plot showing the expression of 22 CTSRs among different cell subsets. A darker grid color indicates higher expression of the regulon. The left dendrogram of the heatmap represents the similarity of expression patterns in the regulon. The top bar of the heatmap represents different cell subsets